SCING—Spinal Cord Injury Neuroprotection with Glyburide: a pilot, open-label, multicentre, prospective evaluation of oral glyburide in patients with acute traumatic spinal cord injury in the USA
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چکیده
منابع مشابه
Pharmacokinetics and safety of oral glyburide in dogs with acute spinal cord injury
Background Glyburide (also known as glibenclamide) is effective in reducing the severity of tissue destruction and improving functional outcome after experimental spinal cord injury in rodents and so has promise as a therapy in humans. There are many important differences between spinal cord injury in experimental animals and in human clinical cases, making it difficult to introduce new therapi...
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Introduction: Spinal cord injury is one of the problems of human societies, which causes many physical and emotional problems for a person and will have consequences for personal, family and social problems. The purpose of this study was to investigate the phenomenological factors affecting post-traumatic growth in patients with spinal cord injury. Methods: The qualitative research project was ...
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The initial experience concerning the use of magnetic resonance imaging in 94 patients who had sustained chronic cord injury showed its specific advantages over traditional imaging modalities. A variety of 84 cord abnormalities were identified including myelomalacia in 47%, cord cysts in 37%, focal atrophy in 11 % and cord transection in 5%. Canal stenosis was seen in twenty-five patients, ...
متن کاملFrequency of Phantom Pain among patients with Spinal Cord Injury
Summary: Background: Patients with spinal cord injury (SCI) usually have permanent and often devastating neurologic deficits and disability and pain (1). According to the National Institutes of Health, "among neurological disorders, the cost to society of automotive SCI is exceeded only by the cost of mental retardation"(2). Neurogenic pain constitutes one of the enigmatic clinical sy...
متن کاملIncidence of Spinal Cord Injury in Traumatic Patients Admitted to a Trauma Referral Center in Guilan
Background & Aim: Patients with spinal cord injury (SCI) impose a heavy burden on health care system. Awareness on prevalence and incidence of SCI is important because this would show the necessity of prevention. This study aimed to investigate the epidemiology and types of traumatic spinal cord injuries in a trauma referral center in Guilan. Methods & Materials/Patients: This is a descripti...
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ژورنال
عنوان ژورنال: BMJ Open
سال: 2019
ISSN: 2044-6055,2044-6055
DOI: 10.1136/bmjopen-2019-031329